If you're 100% cock sure that all 4 of you got no STD of any kind and/or HIV and not worried about "shotgun" the yah very safe. As for the anal thingy, just make sure you wash your willie with soap before going raw virginal sex with gal 3. In fact, never ever stick your willie into any pussy/pussies immediately after anal. If you gonna stick it into the pussy again, give your willie a good wash with soap b4 you put it into the pussy. The gal will suffer from some kind of virginal infection if you dont wash properly. There are some nasty bacteria residing in the rectum.

Those who do anal with condom, change condom before you put it into the pussy.

Do note that I'm not encouraging raw sex in any way.